Emmanuel Eric Pazo

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The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study

Jiayan Chen, Guanghao Qin, Liangzhe Li, Yifan Qi, Xia Yang, Qing Zhang, Yi Wu, Yue You, Lanting Yang, Naici Guo, Salissou Moutari, Jonathan Edward Moore, Shaochong Bu, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He

Ophthalmology and Therapy, 2023 · article · doi:10.1007/s40123-023-00784-z · cited by 14 · Open access (CC BY-NC)

Ocular surface & dry eye

Abstract

INTRODUCTION: The primary objective of this study is to assess whether the combination of intense pulsed light (IPL) with 3% diquafosol (DQS) ophthalmic solution is more effective than intense pulsed light in alleviating signs and symptoms of dry eye disease (DED). METHODS: This randomized study included 66 participants with evaporative dry eye (EDE) who received IPL + DQS therapy (n = 44 eyes), IPL therapy (n = 44 eyes), or sham therapy (n = 44 eyes). All participants were examined at baseline (D0), day 14 (D14), and day 28 (D28) for non-invasive break-up time (NITBUT), tear-film lipid layer (TFLL), corneal conjunctival staining (CS), meibomian gland quality (MGQ), meibomian gland expression (MGEx), and ocular surface disease index (OSDI). RESULTS: At day 28, comparison among the IPL + DQS therapy, IPL therapy, and sham therapy found significant differences in the mean NITBUT (12.03 ± 1.27 versus 10.47 ± 3.48 versus 4.57 ± 0.46; p < 0.001), TFLL (2.09 ± 0.29 versus 2.27 ± 0.45 versus 2.89 ± 0.65; p < 0.001), CS (1.43 ± 0.82 versus 1.93 ± 1.32 versus 3.52 ± 1.00; p < 0.001), MGQ (1.55 ± 0.66 versus 1.91 ± 0.77 versus 2.66 ± 0.53; p < 0.001), MGEx (1.27 ± 0.45 versus 1.75 ± 0.44 versus 2.41 ± 0.50; p < 0.001), and OSDI score (19.36 ± 7.01 versus 24.77 ± 4.68 versus 42.61 ± 7.49; p < 0.001); significant improvements in NITBUT, TFLL, CS, MGQ, MGEx, and OSDI were found in the IPL + DQS therapy and IPL therapy, while the sham therapy had no significant improvements. CONCLUSION: Combining 3% diquafosol ophthalmic solution with intense pulsed light was superior to IPL therapy alone in relieving the signs and symptoms of patients with severe evaporative DED. TRIAL REGISTRATION: Clinical Trials Identifier: NCT05694026.

Keywords: evaporative dry eye; intense pulsed light; meibography; meibomian gland dysfunction; tear film break-up time; tear film lipid layer; corneal and conjunctival staining; Ocular Surface Disease Index

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How to cite

Chen, J., Qin, G., Li, L., Qi, Y., Yang, X., Zhang, Q., Wu, Y., You, Y., Yang, L., Guo, N., Moutari, S., Moore, J. E., Bu, S., Xu, L., He, W., Yu, S., Pazo, E. E., He, X. (2023). The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study. Ophthalmology and Therapy. https://doi.org/10.1007/s40123-023-00784-z

@article{chen2023the,
  title = {{The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study}},
  author = {Chen, Jiayan and Qin, Guanghao and Li, Liangzhe and Qi, Yifan and Yang, Xia and Zhang, Qing and Wu, Yi and You, Yue and Yang, Lanting and Guo, Naici and Moutari, Salissou and Moore, Jonathan Edward and Bu, Shaochong and Xu, Ling and He, Wei and Yu, Sile and Pazo, Emmanuel Eric and He, Xingru},
  journal = {Ophthalmology and Therapy},
  year = {2023},
  doi = {10.1007/s40123-023-00784-z},
  url = {https://doi.org/10.1007/s40123-023-00784-z},
}

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