Emmanuel Eric Pazo

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Hyaluronic Acid Hydrogel as a Retinal Patch in the Treatment of Rhegmatogenous Retinal Detachment: A Multicenter Randomised Parallel‐Controlled Trial

Boshi Liu, Manqiao Wang, Liangzhang Tan, Emmanuel Eric Pazo, Lili Yuan, Qingli Shang, Jingxue Ma, Jianmin Wang, Xiang Ma, Cong Ma, Qinghuai Liu, Jiangdong Ji, Yao Lu, Yong Kang Tao, L Chen, Peiquan Zhao, Jiao Lyn, Qiang Lu, Yan Xia Shao, Xinjun Ren, Xiaorong Li

Clinical and Experimental Ophthalmology, 2025 · article · doi:10.1111/ceo.14570 · cited by 4

Retina & vascular imaging

Abstract

BACKGROUND: To evaluate the efficacy and safety of a linearly cross-linked sodium hyaluronic acid (HA) hydrogel used as a retinal patch in the treatment of rhegmatogenous retinal detachment (RRD). METHODS: This multicenter, randomised, parallel-controlled trial included 313 participants diagnosed with RRD classified as PVR grade A or B, excluding those with giant retinal tears (defined as tears spanning more than one quadrant). Participants were randomly assigned to either an experimental group or a control group. Following laser photocoagulation to retinal breaks, the experimental group received intraocular tamponade with a combination of linearly cross-linked sodium HA hydrogel and sterile air, whereas the control group received intraocular tamponade with perfluoropropane gas (C3F8). According to the intention-to-treat (ITT) principle, the final analysis included 155 subjects in the experimental group and 158 in the control group. The primary outcome measure was the retinal reattachment rate within 24 weeks postoperatively. RESULTS: At 24 weeks, retinal reattachment rates were 91.8% in the experimental group and 91.4% in the control group (p = 0.903), with no statistically significant differences at any follow-up time point. Additionally, there were no significant differences between the two groups regarding best-corrected visual acuity (BCVA), intraocular pressure (IOP), or postoperative complications. CONCLUSIONS: The application of linearly cross-linked sodium HA hydrogel as a retinal patch demonstrated effectiveness comparable to traditional gas tamponade in the treatment of RRD. Furthermore, this method exhibited a favourable safety profile. The technique obviates the need for postoperative prone positioning, significantly improving the patient's postoperative comfort and quality of life. TRIAL REGISTRATION: Chinese Clinical Trial Registry: ChiCTR2000037030.

Keywords: rhegmatogenous retinal detachment; intraocular tamponade; perfluoropropane gas tamponade; retinal reattachment; proliferative vitreoretinopathy; laser photocoagulation; best-corrected visual acuity; postoperative complications

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How to cite

Liu, B., Wang, M., Tan, L., Pazo, E. E., Yuan, L., Shang, Q., Ma, J., Wang, J., Ma, X., Ma, C., Liu, Q., Ji, J., Lu, Y., Tao, Y. K., Chen, L., Zhao, P., Lyn, J., Lu, Q., Shao, Y. X., Ren, X. (2025). Hyaluronic Acid Hydrogel as a Retinal Patch in the Treatment of Rhegmatogenous Retinal Detachment: A Multicenter Randomised Parallel‐Controlled Trial. Clinical and Experimental Ophthalmology. https://doi.org/10.1111/ceo.14570

@article{liu2025hyaluronic,
  title = {{Hyaluronic Acid Hydrogel as a Retinal Patch in the Treatment of Rhegmatogenous Retinal Detachment: A Multicenter Randomised Parallel‐Controlled Trial}},
  author = {Liu, Boshi and Wang, Manqiao and Tan, Liangzhang and Pazo, Emmanuel Eric and Yuan, Lili and Shang, Qingli and Ma, Jingxue and Wang, Jianmin and Ma, Xiang and Ma, Cong and Liu, Qinghuai and Ji, Jiangdong and Lu, Yao and Tao, Yong Kang and Chen, L and Zhao, Peiquan and Lyn, Jiao and Lu, Qiang and Shao, Yan Xia and Ren, Xinjun and Li, Xiaorong},
  journal = {Clinical and Experimental Ophthalmology},
  year = {2025},
  doi = {10.1111/ceo.14570},
  url = {https://doi.org/10.1111/ceo.14570},
}

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