Emmanuel Eric Pazo

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DEVELOPMENT AND PSYCHOMETRIC PROPERTIES OF A QUALITY OF LIFE ASSESSMENT TOOL FOR CHINESE PATIENTS UNDERGOING INTRAVITREAL INJECTION (IVI-QOL-23)

Liangzhang Tan, Wenrui Linghu, Meiqi Xu, Shoukuan Liu, Yongtao Li, Yifeng Ke, Emmanuel Eric Pazo, Xinjun Ren

Retina, 2025 · article · doi:10.1097/iae.0000000000004384 · cited by 1

Retina & vascular imaging

Abstract

PURPOSE: To develop and assess the psychometric properties of a quality-of-life (QoL) assessment tool for Chinese patients treated with intravitreal injection (IVI) of anti-vascular endothelial growth factor. METHODS: We developed a 31-item IVI-QoL questionnaire using semistructured patient interviews and expert panel consultation, drawing on a study of the literature. After pretesting on a subset of patients undergoing IVI, the questionnaire was pared down to 23 items. In total, 364 completed questionnaires were received. The IVI-QoL was further developed and evaluated using Rasch analysis. RESULTS: The final IVI-QoL version was constructed with 23 items in four dimensions: visual function, emotional subscale, social function, and healthy behavior, based on item reduction and exploratory factor analysis. The person separation indices for the four subscales ranged from 2.05 to 2.60. No items had a differential item functioning contrast >0.5 logits. The IVI-QoL-23 scale showed satisfactory internal consistency (Cronbach alpha >0.9). CONCLUSION: The IVI-QoL-23 is reliable and valid for evaluating the QoL of Chinese patients treated with IVI of anti-vascular endothelial growth factor drugs.

Keywords: quality of life; intravitreal injection; anti-VEGF therapy; questionnaire development; psychometric validation; Rasch analysis; Chinese patients; visual function

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How to cite

Tan, L., Linghu, W., Xu, M., Liu, S., Li, Y., Ke, Y., Pazo, E. E., Ren, X. (2025). DEVELOPMENT AND PSYCHOMETRIC PROPERTIES OF A QUALITY OF LIFE ASSESSMENT TOOL FOR CHINESE PATIENTS UNDERGOING INTRAVITREAL INJECTION (IVI-QOL-23). Retina. https://doi.org/10.1097/iae.0000000000004384

@article{tan2025development,
  title = {{DEVELOPMENT AND PSYCHOMETRIC PROPERTIES OF A QUALITY OF LIFE ASSESSMENT TOOL FOR CHINESE PATIENTS UNDERGOING INTRAVITREAL INJECTION (IVI-QOL-23)}},
  author = {Tan, Liangzhang and Linghu, Wenrui and Xu, Meiqi and Liu, Shoukuan and Li, Yongtao and Ke, Yifeng and Pazo, Emmanuel Eric and Ren, Xinjun},
  journal = {Retina},
  year = {2025},
  doi = {10.1097/iae.0000000000004384},
  url = {https://doi.org/10.1097/iae.0000000000004384},
}

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