Emmanuel Eric Pazo

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Effects of Diquafosol Sodium Ophthalmic Solution on Tear Film Matrix Metallopeptidase-9 and Corneal Nerve Density in Patients with Type 2 Diabetic Dry Eye

Guanghao Qin, Jiayan Chen, Liangzhe Li, Yifan Qi, Yimeng Chen, Qing Zhang, Yi Wu, Yue You, Lanting Yang, Naici Guo, Salissou Moutari, Shaochong Bu, Jonathan Edward Moore, Ling Xu, Wei He, Sile Yu, Xingru He, Emmanuel Eric Pazo

Journal of Ocular Pharmacology and Therapeutics, 2023 · article · doi:10.1089/jop.2023.0098 · cited by 9

Ocular surface & dry eye

Abstract

Purpose: Diabetes mellitus has been associated with increased dry eye disease (DED) and exacerbates DED's pathology. This preliminary short-term study aimed to evaluate the effects of 3% Diquafosol Sodium ophthalmic solution (DQS) on ocular surface inflammation and corneal nerve density in diabetic dry eye (DDE) patients. Methods: In this perspective, participants used 1 drop of 3% DQS (Diquas; Santen Pharmaceutical Co., Ltd., Osaka, Japan) 6 times daily for 8 weeks. Non-invasive tear breakup time (NITBUT), tear film lipid layer (TFLL), conjunctival hyperemia [redness score (RS)], corneoconjunctival staining (CFS), corneal sensitivity (CS), Meibomian gland quality (MGQ) and Meibomian gland expressibility (MGEx), corneal nerve fiber density (CNFD), and Standard Patient Evaluation Eye Dryness (SPEED) questionnaire were assessed at baseline, at weeks 4, and up to 8 weeks. Matrix metalloproteinase-9 (MMP-9) of tear samples was measured at baseline and weeks 8. Results: The mean age was 61.27 ± 11.68 years. At baseline NITBUT = 5.89 ± 2.81 s, tear meniscus height = 0.17 ± 0.05 mm, TFLL = 2.74 ± 0.51, CFS = 4.35 ± 0.68, CS = 53.83 ± 9.63 mm, MMP-9 = 49.10 ± 10.42 ng/mL, RS = 1.65 ± 0.44, MGEx = 1.85 ± 0.72, MGQ = 2.65 ± 0.50, CNFD = 20.36 ± 8.20 no./mm 2 , and SPEED = 12.62 ± 3.91. At week 4, significant improvements were found in all parameters except RS (1.59 ± 0.46, P = 0.172) and CNFD (21.46 ± 8.41, P = 0.163). Finally, at week 8, all parameters had significant improvements. Conclusion: Preliminary short-term findings suggest that treatment of DDE patients with DQS was found to be safe and efficacious in improving dry eye parameters. In addition, inflammatory marker and corneal nerve density were significantly improved. This study was registered with ClinicalTrials.gov (NCT05193331).

Keywords: type 2 diabetes; MMP-9; corneal nerve fiber density; corneal innervation; tear film; ocular surface inflammation; meibomian gland dysfunction; tear film lipid layer

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How to cite

Qin, G., Chen, J., Li, L., Qi, Y., Chen, Y., Zhang, Q., Wu, Y., You, Y., Yang, L., Guo, N., Moutari, S., Bu, S., Moore, J. E., Xu, L., He, W., Yu, S., He, X., Pazo, E. E. (2023). Effects of Diquafosol Sodium Ophthalmic Solution on Tear Film Matrix Metallopeptidase-9 and Corneal Nerve Density in Patients with Type 2 Diabetic Dry Eye. Journal of Ocular Pharmacology and Therapeutics. https://doi.org/10.1089/jop.2023.0098

@article{qin2023effects,
  title = {{Effects of Diquafosol Sodium Ophthalmic Solution on Tear Film Matrix Metallopeptidase-9 and Corneal Nerve Density in Patients with Type 2 Diabetic Dry Eye}},
  author = {Qin, Guanghao and Chen, Jiayan and Li, Liangzhe and Qi, Yifan and Chen, Yimeng and Zhang, Qing and Wu, Yi and You, Yue and Yang, Lanting and Guo, Naici and Moutari, Salissou and Bu, Shaochong and Moore, Jonathan Edward and Xu, Ling and He, Wei and Yu, Sile and He, Xingru and Pazo, Emmanuel Eric},
  journal = {Journal of Ocular Pharmacology and Therapeutics},
  year = {2023},
  doi = {10.1089/jop.2023.0098},
  url = {https://doi.org/10.1089/jop.2023.0098},
}

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