Emmanuel Eric Pazo

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Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

Xinmei Zhang, Emmanuel Eric Pazo, Aoqi Zhang, Lanting Yang, Guangzheng Dai, Xianwei Wu, Yang Xia, Amit Meshi, Wei He, Tiezhu Lin

Korean Journal of Ophthalmology, 2022 · article · doi:10.3341/kjo.2021.0081 · cited by 1 · Open access (CC BY-NC)

Retina & vascular imaging

Abstract

PURPOSE: To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement and investigate the associated factors with MSA. METHODS: This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness, subfoveal choroidal thickness, subfoveal scleral thickness were measured on spectral domain optical coherence tomography. Intraclass correlation coefficients of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyze the associated factors with MSA. RESULTS: In total, 135 eyes of 92 patients were enrolled. The mean age was 64.73 ± 10.84 years. Mean MSA on UWF image was 279.67 ± 71.70 mm2. Intraclass correlation coefficients of MSA measurement was 0.965 (95% confidence interval [CI], 0.946 to 0.977; p < 0.001). In the multiple linear regression analysis, after adjusting for subfoveal choroidal thickness, best-corrected visual acuity, central foveal thickness, and subfoveal scleral thickness, the factors independently related to MSA were axial length (β = 8.352; 95% CI, 3.306 to 13.398; p = 0.001), sex (β = -26.673; 95% CI, -51.759 to -1.586; p = 0.037), age (β = 1.184; 95% CI, 0.020 to 2.348; p = 0.046). CONCLUSIONS: It is feasible to measure MSA on UWF image. Female, longer axial length, and older age may indicate larger MSA.

Keywords: ultra-widefield fundus imaging; axial length; sex differences; age; central foveal thickness; subfoveal choroidal thickness; measurement reliability

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How to cite

Zhang, X., Pazo, E. E., Zhang, A., Yang, L., Dai, G., Wu, X., Xia, Y., Meshi, A., He, W., Lin, T. (2022). Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images. Korean Journal of Ophthalmology. https://doi.org/10.3341/kjo.2021.0081

@article{zhang2022factors,
  title = {{Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images}},
  author = {Zhang, Xinmei and Pazo, Emmanuel Eric and Zhang, Aoqi and Yang, Lanting and Dai, Guangzheng and Wu, Xianwei and Xia, Yang and Meshi, Amit and He, Wei and Lin, Tiezhu},
  journal = {Korean Journal of Ophthalmology},
  year = {2022},
  doi = {10.3341/kjo.2021.0081},
  url = {https://doi.org/10.3341/kjo.2021.0081},
}

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