Emmanuel Eric Pazo

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Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study

Yilin Song, Sile Yu, Xingru He, Lanting Yang, Yi Wu, Guanghao Qin, Qing Zhang, Gagan Deep Singh Talwar, Ling Xu, Jonathan Edward Moore, Wei He, Emmanuel Eric Pazo

Preprints.org, 2021 · preprint · doi:10.20944/preprints202103.0017.v1 · Open access (CC BY)

Ocular surface & dry eye

Abstract

Background: Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. Our purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL). Methods: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month. Results: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P<0.05) in the IPL group, while the sham group had no significant improvements. All DE parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards. Conclusion: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears usage.

Keywords: intense pulsed light; evaporative dry eye disease; meibomian gland dysfunction; tear film lipid layer; non-invasive tear break-up time; fluorescein staining; meibomian gland expressibility; Ocular Surface Disease Index

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How to cite

Song, Y., Yu, S., He, X., Yang, L., Wu, Y., Qin, G., Zhang, Q., Talwar, G. D. S., Xu, L., Moore, J. E., He, W., Pazo, E. E. (2021). Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study. Preprints.org. https://doi.org/10.20944/preprints202103.0017.v1

@article{song2021interferometry,
  title = {{Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study}},
  author = {Song, Yilin and Yu, Sile and He, Xingru and Yang, Lanting and Wu, Yi and Qin, Guanghao and Zhang, Qing and Talwar, Gagan Deep Singh and Xu, Ling and Moore, Jonathan Edward and He, Wei and Pazo, Emmanuel Eric},
  journal = {Preprints.org},
  year = {2021},
  doi = {10.20944/preprints202103.0017.v1},
  url = {https://doi.org/10.20944/preprints202103.0017.v1},
}

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