Emmanuel Eric Pazo

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Short-term effects of ophthalmic topical 0.01% atropine on the ocular surface, pupil size, and subsequent subjective quality of vision in young myopic Chinese adults

Mingze Li, Yimeng Chen, Jiayan Chen, Guanghao Qin, Liangzhe Li, Wei He, Sile Yu, Xingru He, Emmanuel Eric Pazo, Ling Xu

Frontiers in Medicine, 2024 · article · doi:10.3389/fmed.2024.1436551 · cited by 10 · Open access (CC BY)

Myopia & refractive errorOcular surface & dry eye

Abstract

Background: Daily use of low concentrations of atropine is recommended for children undergoing myopia control therapy. While the benefits of controlling myopia progression have been confirmed, the potential unwanted side effects on the ocular surface, pupil size, and quality of vision following the administration of 0.01% atropine have not been investigated. Objective: This single-arm, self-control study aimed to investigate the short-term effects of 0.01% atropine topical eye drop (He Eye Hospital Co., Ltd., Shenyang, China) on pupil size and subjective quality of vision in participants with myopia. Each 3 mL vial of eye drops contains atropine (0.01%), sodium chloride (0.9%), and benzalkonium chloride (0.005%) in an aqueous solution. Methods: Thirty-three adults (66 eyes) were recruited for the study. The mean age of the participants recruited for this study was 24.91 ± 3.36 years. This study is registered with Clinical Trials.gov (NCT06071260). Assessments were performed at baseline and 10 h, 14 h, and 18 h following the administration of 0.01% topical atropine drop (TAD). Mesopic pupil diameter (MPD), photopic pupil diameter (PPD), higher order aberration (HOA), non-invasive tear breakup time (NITBUT), tear meniscus height (TMH), tear film lipid layer (TFLL), and Redness score (RS). Subjective assessments included the quality of vision (QoV) and the ocular surface disease index (OSDI) questionnaires. Results: > 0.05) at all time points. Conclusion: Decreased TMH, dry eye symptoms, and visual symptoms will likely persist overnight but often diminish within 18 h after using 0.01% atropine eye drops.

Keywords: atropine; myopia control; pupil size; ocular surface; dry eye; tear film; higher-order aberrations; visual quality

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How to cite

Li, M., Chen, Y., Chen, J., Qin, G., Li, L., He, W., Yu, S., He, X., Pazo, E. E., Xu, L. (2024). Short-term effects of ophthalmic topical 0.01% atropine on the ocular surface, pupil size, and subsequent subjective quality of vision in young myopic Chinese adults. Frontiers in Medicine. https://doi.org/10.3389/fmed.2024.1436551

@article{li2024short,
  title = {{Short-term effects of ophthalmic topical 0.01% atropine on the ocular surface, pupil size, and subsequent subjective quality of vision in young myopic Chinese adults}},
  author = {Li, Mingze and Chen, Yimeng and Chen, Jiayan and Qin, Guanghao and Li, Liangzhe and He, Wei and Yu, Sile and He, Xingru and Pazo, Emmanuel Eric and Xu, Ling},
  journal = {Frontiers in Medicine},
  year = {2024},
  doi = {10.3389/fmed.2024.1436551},
  url = {https://doi.org/10.3389/fmed.2024.1436551},
}

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